解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate the effects of a secondary renal insult, due to chronic infusion of AGEs on renal function, and on early pathological markers in rats with a developmental nephron deficit. METHODS:Female Wistar-Kyoto rats were fed a low-protein diet (LPD; 8.7% casein) or a norma...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-006-0175-x
更新日期:2006-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:In type 2 diabetic patients we compared 9 months of combination therapy with insulin glargine and metformin with 9 months of NPH insulin combined with metformin. The primary focus was changes in HbA(1c); secondary focus was diurnal glucose profiles and symptomatic hypoglycaemia. METHODS:In this investi...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-005-0132-0
更新日期:2006-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Activin receptor-like kinase 7 (ALK7), a member of the type I receptor serine/threonine kinases of the TGF-beta superfamily, was recently reported to regulate cell proliferation and apoptosis. We hypothesised that ALK7 may play a role in modulating pancreatic beta cell proliferation and/or apoptosis. M...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0095-1
更新日期:2006-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The SMXA-5 mouse is one of the SMXA recombinant inbred substrains established from the non-diabetic SM/J and A/J strains, and is a model for polygenic type 2 diabetes, characterised by moderately impaired glucose tolerance and hyperinsulinaemia. These diabetic traits are worsened by feeding a high-fat d...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0121-3
更新日期:2006-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:An increased risk of type 2 diabetes mellitus is associated with low birthweight after full-term gestation, including amplification of this risk by weight gain during infancy and adult body composition. Premature birth is also associated with insulin resistance, but studies conducted so far have not pro...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0118-y
更新日期:2006-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme and its products, such as prostaglandin E(2) (PGE(2)), have been implicated in the pathogenesis of several inflammatory diseases including islet dysfunction under diabetic conditions. In this study we evaluated whether diabetic conditions in ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0065-7
更新日期:2006-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:We determined the response of selected genes to in vivo insulin in adipose tissue in 21 non-diabetic women. MATERIALS AND METHODS:The women were divided into insulin-sensitive and -resistant groups based on their median whole-body insulin sensitivity (8.7+/-0.4 vs 4.2+/-0.3 mg kg(-1) min(-1) for insuli...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0075-5
更新日期:2006-01-01 00:00:00
abstract:AIMS/HYPOTHESIS:African-Americans with type 2 diabetes and access to adequate healthcare are at lower risk of clinical coronary artery disease than are white diabetic patients. We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0017-2
更新日期:2005-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. METHODS:We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the ye...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-0033-2
更新日期:2005-12-01 00:00:00
abstract:AIMS/HYPOTHESIS:Increased expression and decreased degradation of extracellular matrix (ECM) proteins are key features of chronic diabetic complications. Fibronectin, a predominant ECM protein, has been shown to be overexpressed in all target organs of diabetic complications and in endothelial cells cultured in high le...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1939-4
更新日期:2005-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:Uncoupling protein-2 (UCP2) is thought to play a role in insulin secretion and the development of obesity. In this study, we investigated the effects of genetic variation in UCP2 on type 2 diabetes and obesity, as well as on metabolic phenotypes related to these diseases, in Pima Indians. METHODS:The c...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1934-9
更新日期:2005-11-01 00:00:00
abstract:AIMS/HYPOTHESIS:The transcription factor upstream stimulatory factor 1 (USF1) regulates the expression of genes involved in glucose and lipid metabolism and has been associated with familial combined hyperlipidaemia. USF1 is located on chromosome 1q22-23, a region with evidence for linkage to type 2 diabetes and variou...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1914-0
更新日期:2005-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:We sought to elucidate whether excess glucocorticoids and increased dietary lipids act synergistically to impair glucose tolerance and, if so, whether activation of peroxisome proliferator-activated receptor alpha (PPARalpha) has an adverse or beneficial effect on glucose tolerance. METHODS:Dexamethaso...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1894-0
更新日期:2005-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Preferential visceral adipose tissue (VAT) accumulation has been clearly associated with insulin resistance. In contrast, the impact of visceral obesity on beta cell function is controversial. METHODS:In 62 non-diabetic women and men (age 24-69 years, BMI 21-39 kg/m2), we measured VAT and subcutaneous ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1891-3
更新日期:2005-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperinsulinaemia and insulin resistance, as well as low IGF-I, have been implicated in the pathogenesis of cardiovascular disease. Little is known about direct effects of IGF-I and insulin on human coronary artery smooth muscle cells (HCASMCs). Our aim was to characterise the expression and function of...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1890-4
更新日期:2005-10-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion. MATERIALS AND METHODS:We hypothesised that glucose concentratio...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1860-x
更新日期:2005-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The islet microcirculation has morphological characteristics resembling those of renal glomeruli. Transcription of the nephrin gene, a highly specific barrier protein of the slit diaphragm of podocyte foot processes, has been reported in the pancreas, although its cellular localisation and function rema...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1865-5
更新日期:2005-09-01 00:00:00
abstract:AIMS/HYPOTHESIS:The study was designed to identify the key metabolic signals of glucose-stimulated proinsulin gene transcription and translation, focusing on the mechanism of succinate stimulation of insulin production. METHODS:Wistar rat islets were incubated in 3.3 mmol/l glucose with and without esters of different...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1811-6
更新日期:2005-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:No previous studies on the association between salt intake and the risk of type 2 diabetes have been reported. The aim of this study was to assess whether high salt intake, measured by 24-h urinary sodium excretion, is an independent risk factor for type 2 diabetes. METHODS:We followed prospectively 93...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1824-1
更新日期:2005-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:Hyperglycaemia in diabetes is associated with increased glycation, oxidative stress and nitrosative stress. Proteins modified consequently contain glycation, oxidation and nitration adduct residues, and undergo cellular proteolysis with release of corresponding free adducts. These free adducts leak into...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1810-7
更新日期:2005-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:It is thought that enterovirus infections initiate or facilitate the pathogenetic processes leading to type 1 diabetes. Exposure of cultured human islets to cytolytic enterovirus strains kills beta cells after a protracted period, suggesting a role for secondary virus-induced factors such as cytokines. ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1839-7
更新日期:2005-08-01 00:00:00
abstract:AIMS/HYPOTHESIS:The gut hormone glucagon-like peptide-1 (GLP-1) decreases beta cell apoptosis in a protein kinase B (PKB)-dependent fashion, and increases islet cell mass and function in vivo. In contrast, cytokines induce beta cell apoptosis, leading to decreased islet mass and type 1 diabetes. In the present study we...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1787-2
更新日期:2005-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to assess the predictive role of autonomic reactivity in body weight loss induced by gastric bypass. METHODS:A group of 22 morbidly obese subjects, who were due to undergo a gastric bypass, were submitted, before surgery, to a euglycaemic-hyperinsulinaemic clamp, during which ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1792-5
更新日期:2005-07-01 00:00:00
abstract:AIMS/HYPOTHESIS:Leptin resistance is generally considered a consequence of obesity. We postulated that leptin resistance is associated with diminished hypothalamic leptin signalling capacity and that leptin resistance is causal to obesity. We assessed maximal leptin-mediated binding of the transcription factor signal t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1763-x
更新日期:2005-06-01 00:00:00
abstract:AIMS/HYPOTHESIS:Gestational diabetes mellitus (GDM) identifies a population of young women at high risk of developing type 2 diabetes and thus provides an excellent model for studying early events in the natural history of this disease. Adiponectin, a novel adipocyte-derived protein with insulin-sensitising properties,...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1710-x
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Diabetic distal symmetrical sensory polyneuropathy (DSP) affects 20-30% of diabetic patients. Transcutaneous electrical nerve stimulation (TENS) and electrical spinal cord stimulation have been proposed as physical therapies. We performed a controlled, randomised pilot trial to compare the effects of hi...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00125-005-1728-0
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:This study estimated the economic efficiency (1) of intensive blood glucose control and tight blood pressure control in patients with type 2 diabetes who also had hypertension, and (2) of metformin therapy in type 2 diabetic patients who were overweight. METHODS:We conducted cost-utility analysis based...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1717-3
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Although the variable number tandem repeat (VNTR) minisatellite 5' to the insulin gene is among the most studied polymorphisms in diabetes, the relationships between VNTR variation, diabetes-related traits and predisposition to type 2 diabetes remain unclear. Since inadequate sample size is likely to ha...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-005-1737-z
更新日期:2005-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to evaluate the relationship between benign prostatic hyperplasia (BPH) and arteriosclerosis shown in a model of type 2 diabetes in a trans-sectional population study using contrast-enhanced colour Doppler ultrasound for exact assessment of prostatic blood flow. METHODS:Contra...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1678-6
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to study differences in the prevalence of the metabolic syndrome and its associations with prevalent CHD according to ethnicity and sex. METHODS:We performed a combined analysis of two population-based cross-sectional studies conducted between 1988 and 1991 that followed ident...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1689-3
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:We examined the prevalence of islet autoantibodies and their relationship to glycaemic control over 10 years in patients diagnosed clinically with new-onset type 2 diabetes. METHODS:Patient clinical characteristics and autoantibody status were determined at entry to the UK Prospective Diabetes Study (U...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1007/s00125-005-1690-x
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Osmotic and oxidative stress is associated with the progression and advancement of diabetic cataract. In the present study, we used a cDNA microarray method to analyse gene expression patterns in streptozotocin-induced diabetic rats and galactose-fed cataractous lenses. In addition, we investigated the ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1687-5
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determined which of the in vivo actions of insulin are impaired in this condition. METHODS:We performed...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-005-1682-x
更新日期:2005-04-01 00:00:00
abstract:AIMS/HYPOTHESIS:Recent studies have demonstrated that pioglitazone (PIO) has beneficial effects on insulin sensitivity compared with placebo in patients with type 2 diabetes. The effects of PIO and gliclazide (GLIC)-based therapy on insulin sensitivity have not previously been directly compared. This analysis aimed to ...
journal_title:Diabetologia
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1007/s00125-004-1651-9
更新日期:2005-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:The aim of this study was to investigate molecular mechanisms of glucose-induced changes in islets of Langerhans by analysing global changes in protein patterns of islets exposed to elevated glucose concentrations. METHODS:Islets were isolated from C57BL/6J mice and used either directly or after exposu...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1661-7
更新日期:2005-03-01 00:00:00
abstract:AIMS/HYPOTHESIS:Previous studies have implicated the glycoxidative modification of low-density lipoprotein (LDL) by glucose and aldehydes (apparently comprising both glycation and oxidation), as a causative factor in the elevated levels of atherosclerosis observed in diabetic patients. Such LDL modification can result ...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1648-4
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The pathogenesis of vascular complications in type 1 diabetes is poorly understood, but may involve chronic, low-grade inflammation. We investigated the association of markers of inflammation with vascular complications in type 1 diabetes. METHODS:A cross-sectional nested case-control study of the foll...
journal_title:Diabetologia
pub_type: 杂志文章,多中心研究
doi:10.1007/s00125-004-1628-8
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:To document the prevalence of typical diabetic symptoms, signs and complications in the diagnosis of type 2 diabetes mellitus, examine their pre-diagnostic duration, and analyse associations with glycaemic level, blood pressure (BP), and weight. METHODS:An epidemiological population-based study of 1137...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1625-y
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Glomerular mesangial expansion is a characteristic feature of diabetic nephropathy, and the accumulation of AGE in the mesangial lesion has been implicated as one of its potential causes. However, the route for the AGE accumulation in mesangial lesions in diabetic patients is poorly established. METHOD...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1646-6
更新日期:2005-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:Fulminant type 1 diabetes, which is characterised by a markedly acute onset of diabetes and an absence of islet-related autoantibodies, accounts for 20% of type 1 diabetes in Japan. We aimed to clarify the contribution of the HLA subtype to fulminant type 1 diabetes in Japanese. METHODS:We determined t...
journal_title:Diabetologia
pub_type: 杂志文章
doi:10.1007/s00125-004-1626-x
更新日期:2005-02-01 00:00:00